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Cancers of the anal canal: diagnosis, treatment and future strategies

Cancers of the anal canal: diagnosis, treatment and future strategies

Emma Bown, Vikas Shah, Thiagarajan Sridhar, Kirsten Boyle, David Hemingway, Justin M Yeung

ABSTRACT: Anal cancer is an uncommon cancer; however, it is rising in incidence. There is confusion regarding nomenclature and the distinction between anal canal cancer and anal margin cancer. This article discusses the modern definition, etiology and staging of anal canal and anal margin cancers. Modern chemotherapy and radiotherapy regimens are discussed, in addition to modern imaging and radiotherapy techniques. Future preventative strategies and potential novel treatments are discussed.

Future Oncology, June 2014, Vol. 10, No. 8 , Pages 1427-1441
doi: 10.2217/fon.14.23