Cervical Cancer Screening (PDQ®) - National Cancer Institute

Información del Instituto Nacional del Cancer de los EEUU en relación con el Despistaje del Carcinoma de Cuello Uterino. Información para pacientes sobre los Exámenes de detección del cáncer de cuello uterino (PDQ®).

Admin Eusalud

The history of pathology informatics

The history of pathology informatics: A global perspective

Seung Park, Anil V. Parwani, Raymond D. Aller, Lech Banach, Michael J. Becich, Stephan Borkenfeld, Alexis B. Carter, Bruce A. Friedman, Marcial Garcia Rojo, Andrew Georgiou, Gian Kayser, Klaus Kayser, Michael Legg, Christopher Naugler, Takashi Sawai, Hal Weiner, Dennis Winsten, and Liron Pantanowitz

Abstract: Pathology informatics has evolved to varying levels around the world. The history of pathology informatics in different countries is a tale with many dimensions. At first glance, it is the familiar story of individuals solving problems that arise in their clinical practice to enhance efficiency, better manage (e.g., digitize) laboratory information, as well as exploit emerging information technologies. Under the surface, however, lie powerful resource, regulatory, and societal forces that helped shape our discipline into what it is today. In this monograph, for the first time in the history of our discipline, we collectively perform a global review of the field of pathology informatics. In doing so, we illustrate how general far-reaching trends such as the advent of computers, the Internet and digital imaging have affected pathology informatics in the world at large. Major drivers in the field included the need for pathologists to comply with national standards for health information technology and telepathology applications to meet the scarcity of pathology services and trained people in certain countries. Following trials by a multitude of investigators, not all of them successful, it is apparent that innovation alone did not assure the success of many informatics tools and solutions. Common, ongoing barriers to the widespread adoption of informatics devices include poor information technology infrastructure in undeveloped areas, the cost of technology, and regulatory issues. This review offers a deeper understanding of how pathology informatics historically developed and provides insights into what the promising future might hold.

PMC: 3714902

J Pathol Inform. 2013; 4: 7. May 30, 2013. doi: 10.4103/2153-3539.112689

XII International Workshop of Lower Genital Tract Pathology

XII International Workshop of Lower Genital Tract Pathology. Roma 5 al 7 de Marzo del 2015

Welcome Message

Dear Colleagues,

Antonio Frega, Philip Davies and I, Cesare Gentili, are pleased to announce the XII Workshop of Lower Genital Tract Pathology which will be held in Rome from March 5th to 7th 2015.
These Workshops have a unique multidisciplinary nature covering all disciplines related to diseases of the lower genital tract.
The last Workshop was attended by over 500 participants from 39 countries and with 55 speakers of international renown who maintained the participants’ interest for the entire congress by delivering a challenging and comprehensive program. We have no doubt that the upcoming congress will be an even bigger success.
For 2015, we have made some changes to the program by introducing some innovative elements in order to make it a more dynamic workshop while still keeping a sharp focus on the new issues that are of interest to clinicians and scientific validity.
More time will be allowed for debates, particularly in the specialized sessions on topics of interest in daily practice. There will be four interactive sessions, two for gynaecologists and two for pathologists, that will be based on clinical cases presentations using slides and videos. In each specialisation, one session will be led by the speakers and the other by the participants who will present previously selected cases. And there will be the new Twitter style Sessions, an effective way to summarize the salient points of the day.
After the success of the “Free Communications” in the previous Workshop, we have decided to repeat it this year too. Prizes will be given to the best three communications during the plenary session. Moreover, the participants will have the opportunity to vote for their favourite speaker and prizes will be given to the best three.
The multidisciplinary nature of the Workshop will allow experts from different fields to follow the topics of common interest in the plenary session as having the opportunity to learn about the latest development in their own specialist areas. The program will have a logical progression without duplications or overlap.
As in previous Workshop, the XII edition will have lectures covering the latest issues in cervical cancer prevention, diagnosis and treatment, and it will have the most highly respected researchers and clinicians from Italy and the rest of the world.
Although the congress has an international character, the atmosphere is informal and simple, and you can spend some pleasant days in Rome with us enjoying the typical dishes of the evocative Roman restaurants.

We now look forward to welcoming you to the XII Workshop of Lower Genital Tract Pathology in Rome next year.

With our best regards,

The Course Coordinators


Actualizaciones sobre las Neoplasias Vulvares Intraepiteliales (VIN) (Revisión)

An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis

M Carolina Reyes, Kumarasen Cooper

Abstract: There are two distinct types of vulvar intraepithelial neoplasia (VIN), which differ in their clinical presentation, aetiology, pathogenesis and histological/immunophenotypical features. One form driven by high-risk human papilloma virus infection usually occurs in young women and has been termed classic or usual VIN (uVIN). The other, not related to viral infection, occurs in postmenopausal women with chronic skin conditions such as lichen sclerosus and lichen simplex chronicus and is termed differentiated or simplex-type VIN. The latter is the precursor lesion of the most common type of squamous cell carcinoma (SCC) in the vulva, namely keratinizing SCC (representing 60% of cases). In contrast, uVIN usually gives rise to basaloid or warty SCC (40% of cases). The histological features of uVIN are similar to those of high grade lesions encountered in other lower anogenital tract sites (hyperchomatic nuclei with high nuclear to cytoplasmic ratios and increased mitotic activity). However, differentiated VIN has very subtle histopathological changes and often escapes diagnosis. Since uVIN is driven by high-risk human papilloma virus infections, p16 immunohistochemistry is diffusely positive in these lesions and is characterized with a high Ki-67 proliferation index. In contrast, differentiated or simplex-type VIN is consistently negative for p16 and the majority of the cases harbour TP53 mutations, correlating with p53 positivity by immunohistochemistry.

J Clin Pathol 2014;67:290-294 doi:10.1136/jclinpath-2013-202117


#Manifiesto2014 Científicos por el derecho a vivir

Madrid, 25 de febrero de 2014

Querido compañero:

Como sabes, el Gobierno ha prometido reformar la ley del aborto en el sentido de dar una mayor protección a la vida prenatal.

Recientemente hemos solicitado la adhesión a esta carta-manifiesto a un gran número de médicos españoles, en la que manifestamos nuestro apoyo al Gobierno en el paso dado hacia una mayor protección de la vida prenatal y solicitamos mejoras para conseguir disminuir las cifras de aborto en España.

La respuesta ha sido enormemente satisfactoria, no solamente por parte de los médicos sino por parte de muchos otros profesionales de la Sanidad y científicos que nos han propuesto extender esta solicitud de adhesión a estos otros colectivos de profesionales.

Es por esto que nos dirigimos nuevamente a vosotros para haceros extensiva la invitación a suscribir a esta carta: si en los días previos no habéis podido firmarla por estar dirigida al colectivo médico, ya podéis adheriros y difundirla entre todos vuestros compañeros.

Esperamos poder contar con tu firma y mostrar así a la opinión pública que somos muchos los médicos y profesionales que queremos cuidar a nuestros pacientes y ofrecer todas las alternativas necesarias para que las mujeres gestantes puedan seguir adelante con sus embarazos, asegurando también que se respete el derecho a la vida de sus hijos.

Muchas gracias por tu apoyo.

José Ignacio Sánchez Méndez
Sonsoles Alonso Salvador
Mª Jesús López Rodríguez
Esteban Rodríguez Martín
José Manuel Tubío Echagüe
Gádor Joya Verde

Médicos especialistas en Pediatría, Ginecología y Obstetricia


Declaración de Dublín sobre Salud Materna

Declaración de Dublín sobre Salud Materna (Septiembre 2012)

Dublin Declaration

“Como investigadores y médicos experimentados en Ginecología y Obstetricia, afirmamos que el aborto inducido – la destrucción deliberada del no nacido – no es médicamente necesaria para salvar la vida de una mujer.

Sostenemos que existe una diferencia fundamental entre el aborto y los tratamientos necesarios que se llevan a cabo para salvar la vida de la madre, aún si aquellos tratamientos dan como resultado la pérdida de la vida del niño no nacido.

Confirmamos que la prohibición del aborto no afecta, de ninguna manera, la disponibilidad de un cuidado óptimo de la mujer embarazada.”

Si usted es un profesional médico o estudiantes de medicina, por favor Firme la Declaración!

Si quiere firmar ésta declaración, siga por favor el vínculo

REA VOL 11, NÚM. 2 (2013)


La REA/EJA se centra en la Autopsia Clínica y Forense y con ella en las mejoras en cuanto a calidad asistencial y pericial. En cada número se presentan artículos originales, artículos de revisión y comentarios de internet así como exposición de casos interesantes acompañados de magníficas ilustraciones. Cobertura abarca métodos técnicos y ayudas de diagnóstico.

Novedades sobre el Ca de cervix y ERB2; carta en Nature

Landscape of genomic alterations in cervical carcinomas

Akinyemi I. Ojesina, Lee Lichtenstein, Samuel S. Freeman, et al.

Cuidado con los resultados de p16 negativos en CIN-2

HPV Detection and p16INK4a Expression in Cervical Lesions. A Comparative Study

Jordi Genovés, Frances Alameda, Gemma Mancebo, Josep Maria Solé,

Abstract: p16INK4a expression in dysplastic cervical lesions is related to high-risk human papillomavirus (HR-HPV) infection. The immunohistochemical expression of this protein in these lesions allows an increase in diagnostic reproducibility in biopsies and the introduction of prognostic factors in low-grade lesions. Here, we studied the immunohistochemical expression of p16 in 86 dysplastic cervical lesions, 54 cervical intraepithelial neoplasms - grade 1 (CIN-I), 23 CIN-II, and 9 CIN-III. In addition, we performed HPV detection and genotyping. We detected HR-HPV in 19/54 CIN-I, 21/23 CIN-II and 9/9 CIN-III cases. p16 INK4a immunoreactivity was observed in 7/19 CIN-I HR-HPV–positive, 17/21 CIN-II HR-HPV–positive and all CIN-III cases. Immunoreactivity for p16 INK4a was found in 7/54 CIN-I and in 17/23 CIN-II cases. In the follow-up, we detected 3 p16-positive high-grade squamous epithelial lesions (HSIL: CIN-II and CIN-III) in the CIN-I/p16-negative group and 5 p16-positive HSIL cases in the CIN-II/p16-negative group. We conclude that p16 negativity in CIN-I and CIN-II biopsies does not always imply regression of the lesion and that the diagnosis of CIN-II should not be based solely on p16 results.

Human Pathology Full-length article (In Press Accepted Manuscript) doi:10.1016/j.humpath.2013.10.035

Admin Eusalud

VPH y cáncer de laringe

Correlation of Laryngeal Squamous Cell Carcinoma and Infections with Either HHV-8 or HPV16/18

Nema Mohamadian Roshaa, Amirhossein Jafariaa, Hossein Ayatollah, Kiarash Ghazvini, Seyyed Abbas Tabatabaee

Abstract: Each year more than 159,000 new cases of laryngeal cancer are diagnosed globally, and more than 9000 patients die due to this malignancy. Viral infections are a known risk factor for this malignancy. Thus, this study aimed to evaluate the role of HPV-16/18 and HHV-8 infection in patients with laryngeal cancer. In this case–control study, 60 formalin-fixed, paraffin-embedded samples of laryngeal cancer and 22 normal larynx tissue samples from the Pathology Department of Qaem Hospital, Mashhad, Iran were studied. After validating the diagnosis, the samples were evaluated for the detection of HPV-16/18 and HHV-8 DNA using PCR technique. The data were registered and analyzed using SPSS 18.0. The average age for patients and controls was 61.29 ± 11.89 and 55.77 ± 10.10, respectively. Fifty-four patients (90%) and 16 (72.7%) controls were male. PCR results detected no HPV-16/18 DNA in both groups. Although there were 2 positive HHV-8 samples in both laryngeal cancer and normal larynx samples, no significant relation was present (p = 0.291). We found no significant relationship between infection with HHV-8 or HPV-16/18 and the existence of laryngeal cancer. However, more complementary studies are required to re-evaluate our results using more samples and better viral detection techniques.

Pathology - Research and Practice. Available online 12 December 2013.

Admin Eusalud

Una única dosis de la vacuna VPH puede ser válida

One dose of HPV vaccine may be sufficient to prevent cervical cancer - ONA

Kathy Boltz, PhD
November 20, 2013

Women vaccinated with one dose of a human papillomavirus (HPV) vaccine had antibodies against the viruses that remained stable in their blood for 4 years, suggesting that a single dose of vaccine may be sufficient to generate long-term immune responses and protection against new HPV infections, and ultimately cervical cancer, according to a new study.

"The latest Morbidity and Mortality Weekly Report from the Centers for Disease Control and Prevention on vaccination coverage indicates that in 2012, only 53.8% of girls between 13 and 17 years old initiated HPV vaccination, and only 33.4% of them received all three doses," said lead author Mahboobeh Safaeian, PhD, an investigator in the Division of Cancer Epidemiology and Genetics at the National Cancer Institute (NCI) in Bethesda, Maryland.

12th European Congress on Digital Pathology

12th European Congress on Digital Pathology

previously European Congress on Telepathology and International Congress on Virtual Microscopy

Worldwide INDUSTRY, RESEARCH and CLINICS participants:

   - Business processes in Pathology: hospital integration, telepathology, e-learning
   - Imaging technological advances: WSI, molecular imaging, label free technologies...
   - Image analysis, knowledge formalization and modeling

Organized under the presidency of Catherine Guettier SFP (French Society of  Pathology), honorary president, Etienne Martin with the contribution of ADICAP (Association for Developing Informatics in Cytology and Anatomic Pathology), Frédérique Capron and GFHC (French Group for Cellular Haematology),
Xavier Troussard.

Dear Sir / Madam,

we would like to invite you to the 12th European Congress on Digital Pathology, previously kwown as European Congress on Telepathology and International Congress on Virtual Microscopy, to be held in Paris, France from 18 to 21 June 2014.

Pathology switch from analogue to digital is at the centre of the Congress, as shown in the agenda below. This congress represents a great chance to learn about latest and future innovations and we warmly invite you, your colleagues and partners to attend this biennial European event with participants from all over the world.

This edition of the Congress is organized under the presidence of Catherine Guettier SFP (French Society of Pathology), honorary president, Etienne Martin
with the contribution of ADICAP (Association for Developing Informatics in Cytology and Anatomic Pathology), Frédérique Capron and GFHC (French Group for Cellular Haematology), Xavier Troussard.


Abstracts submission deadline: 20 January 2014

- Contributors are invited to submit an abstract (max. 400 words) written in English for oral and poster presentations on all research fields related to digital pathology, telepathology, image analysis. Specific topics include (and are not limited to) the topics from the provisional agenda underneath.

- Submission should be done electronically at the following link: before 20 January 2014

- In addition, contributors who also aim at individually Pubmed indexed articles shall submit an extended abstract (less than 1500 words). Selected articles will be published either in "Diagnostic Pathology" (editor-in-chief Klaus Kayser, co-chairs Catherine Bor, Philippe Camparo and Myriam Oger) or for computer science oriented articles in the "Computerized Medical Imaging and Graphics" Elsevier journal (editor-in-chief Daniel Racoceanu, co-chair Philippe Belhomme)

NEW! Pecha kucha - a great opportunity for young scientists and creative senior researchers!
Pecha kucha is a special form for very dynamic and exciting presentations. You will have the chance to present your topic/idea/projects (no limits!) for discussion, idea mining and potential collaborators.
The rules of Pecha kucha are very simple: you have 20 slides, for each slide exactly 20 seconds to speak (for the complete presentation 6 min 40 sec). For this session maximal seven words per slide are allowed, you have to use images, figures and diagrams to present you scientific topic, question, idea and/or opinion. This strict format keeps presentations creative, concise and fast-paced and avoids the "Powerpoint-Death"Â (more details:
Please send only your name and title of the Pecha kucha-Presentation to: - no abstracts are necessary.

Organizing committee co-chaired by Jacques Klossa and Philippe Bertheau: Philippe Belhomme; Catherine Bor; Philippe Camparo; Odile Crepin; Christel Daniel; Bettina Fabiani; Vincent Leymarie; Daniel Lusina; Michel Manfait; Etienne Martin; Myriam Oger; Daniel Racoceanu; Thomas Schrader; Béatrice Vergier

Scientific advisory board co-chaired by Klaus Kayser, Catherine Bor and Daniel Racoceanu

Provisional agenda

Wednesday 18 June, 2014
IHE/DICOM joint meeting and at the same time "Young colleagues training session"
Congress opening at 18:00

Thursday 19 June, 2014
Keynote on telepathology
- Telepathology
- Image analysis
- Digital pathology / Virtual microscopy / Technological advances
- Posters presentation and session - PECHA KUCHA for young students

Friday 20 June, 2014
Keynote on knowledge formalization
- Knowledge formalisation
- E- learning
- Image analysis
- Posters presentation and session - PECHA KUCHA for young students

Saturday 21 June, 2014
Keynote on data mining and modeling
- Data mining
- Models in pathology
- Quality of experience

Organizing Secretariat

the office

in collaboration with
Meeting di Sara Zanazzi

For any further information or request, please visit the Congress website or contact the Organizing Secretariat.

Best regards,

Luciana Biecker

HPV&HIV en lesiones de ano

Human papillomavirus genotypes in human immunodeficiency virus-positive patients with anal pathology in Madrid, Spain.

Benjamín García-Espinosa, Ernesto Moro-Rodríguez and Emilio Álvarez-Fernández

Background: We studied anal specimens to determine the distribution of human papillomavirus (HPV) genotypes and co-infection occurrence. This information will contribute to the knowledge of HPV genotype distributions and provide an estimate of the prevalence of different oncogenic HPV genotypes found in patients in Madrid (Spain). Methods: We studied a total of 82 anal biopsies from the Hospital General Universitario Gregorio Marañón of Madrid. These included 4 specimens with benign lesions, 52 specimens with low-grade anal squamous intraepithelial lesion, 24 specimens with high-grade anal squamous intraepithelial lesions and 2 specimens with invasive anal carcinoma. HPV genotyping was performed with PCR amplification and reverse dot blot hybridization. Results: We detected 33 different HPV genotypes, including 16 HPVs associated with a high risk of carcinogenesis, 3 HPVs associated with a highly likely risk of carcinogenesis and 14 HPVs associated with a low-risk of carcinogenesis. In two specimens, an uncharacterized HPV genotype was detected. The most frequent HPV genotypes found were HPV-16 (10.3%; 95% CI: 6.6%-15.1%), HPV-52 (8.5%; 95% CI: 5.2%-13%) and HPV-43/44 (7.6%; 95% CI: 4.5%-11.9%). HPV-18 was only detected in 0.9% (95% CI: 0.1%-3.2%) of the total viruses detected in all lesions. HPV co-infections were found in 83.9% of all types of lesions. The majority of cases (90.2%) were concomitantly infected with the human immunodeficiency virus (HIV). Conclusion: The prevalence of high-risk carcinogenic genotypes in anal pathological samples was remarkable. Therefore, further studies that include a greater number of samples, particularly invasive carcinoma cases are needed to evaluate the potential influence of these HPV genotypes in the appearance of anal carcinomas. Also, the influence of other accompanying infections should be evaluated clarify the appearance of this type of carcinoma.

Diagnostic Pathology 2013, 8:204 doi:10.1186/1746-1596-8-204

Published: 10 December 2013