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The Occasional Role of Low-risk Human Papillomaviruses 6, 11, 42, 44, and 70 in Anogenital Carcinoma

The Occasional Role of Low-risk Human Papillomaviruses 6, 11, 42, 44, and 70 in Anogenital Carcinoma Defined by Laser Capture Microdissection/PCR Methodology: Results From a Global Study

Guimerà, Núria; Lloveras, Belén; Lindeman, Jan; Alemany, Laia; van de Sandt, Miekel; Alejojo, Maria; Hernandez-Suarez, Gustavo; Bravo, Ignacio G.; Molijn, Anco; Jenkins, David; Cubilla, Antonio; Muñoz, Nubia; de Sanjose, Silvia; Bosch, Francesc Xavier; Quint, Wim

Abstract: Low-risk human papillomaviruses (LR-HPVs) have been associated occasionally with clinically and pathologically unusual anogenital malignancies. The relation between clinicopathologic features and any pathogenetic role of LR-HPV remains unclear. From a global study of 13,328 anogenital carcinomas, we identified 57 cases in which whole-tissue polymerase chain reaction using SPF10-LiPA25 showed single LR-HPV infection. In 43/46 (93.5%) available carcinomas, multiple polymerase chain reaction assays confirmed single detection of HPV6, 11, 42, 44, or 70 DNA. In 75% (n=32) of these, LR-HPV DNA was confirmed in tumor cells by laser capture microdissection. In 2 cases, including 1 adenocarcinoma, viral DNA was only found outside the tumor. All anogenital tumors with confirmed HPV6/11 showed a distinctive range of papillary, warty or warty-basaloid, squamous, or transitional histology with patchy or negative p16INK4a expression. HPV6-associated cervical tumors occurred at a low median age. HPV42/70 was associated with typical squamous cell carcinoma showing diffuse p16INK4a staining like high-risk HPV–related malignancies. HPV44 was found in malignant cells in 1 case. Viral taxonomy and theoretical analysis show that HPV6/11 belong to a different genus from HPV42/70 with E6/E7 gene products that would not bind pRb or p53, whereas HPV42/70 could bind pRb. Our data support the causal involvement of LR-HPVs in the carcinogenesis of <2% of anogenital malignancies of 2 distinct clinicopathologic patterns related to the genetic structure of the HPV types 6/11 and 70/42. HPV42/70 was associated with typical squamous carcinomas. Importantly all carcinomas associated with HPV6/11 globally showed verruco-papillary, well-differentiated, squamous, or transitional histology without p16INK4a expression.

Am J Surg Pathol September 2013 - Volume 37 - Issue 9 - p 1299–1310
doi: 10.1097/PAS.0b013e31828b6be4

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Data Science Toolbox

Start doing data science in minutes

Data Science Toolbox

As a data scientist, you don't want to waste your time installing software. Our goal is to provide a virtual environment that will enable you to start doing data science in a matter of minutes.

As a teacher, author, or organization, making sure that your students, readers, or members have the same software installed is not straightforward. This open source project will enable you to easily create custom software and data bundles for the Data Science Toolbox.

datasciencetoolbox.org

Datasets and Tissue Pathways

Datasets and Tissue Pathways

The Royal College of Pathologist

The College's Standards and Datasets for Histopathology Reporting on Cancers and Tissue Pathways have been written to help pathologists work towards a consistent approach for the reporting of the more common cancers and to define the range of acceptable practice in handling pathology specimens. The table in their web page provides links to the cancer dataset documents and to the 'tissue pathways' for non-malignant diseases for each site. NICE has accredited the process used by The Royal College of Pathologists to produce its Cancer Datasets and Tissue Pathways guidance. Accreditation is valid for five years from July 2012 and is retrospectively applicable to documents produced using the processes described in our 2012 guidelines for writing datasets and tissue pathways. All guidance produced following the accredited process bears the NICE accreditation mark. More information on accreditation can be viewed at nice.org.uk/acreditation

Click for more information on datasets, tissue pathways and the Working Group on Cancer Services, including guidance for authors.

Fuente: Datasets and Tissue Pathways

Sida en EE.UU.

HIV in the United States – Statistics Overview – Statistics Center – HIV/AIDS.

Figure: Estimated New HIV Infections in the United States, 2010, for the Most Affected Subpopulations

CDC - HIV in the United States: At A Glance

Fast Facts

  • More than 1.1 million people in the United States are living with HIV infection, and almost 1 in 6 (15.8%) are unaware of their infection.
  • Gay, bisexual, and other men who have sex with men (MSMa), particularly young black/African American MSM, are most seriously affected by HIV.
  • By race, blacks/African Americans face the most severe burden of HIV.

Fuente: HIV in the United States: At A Glance

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Admin Eusalud

Elucinan la causa de la caquexia en pacientes con cáncer

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

Michele Petruzzelli, Martina Schweiger, Renate Schreiber, Ramon Campos-Olivas, Maria Tsoli, John Allen, Michael Swarbrick, Stefan Rose-John, Mercedes Rincon, Graham Robertson, Rudolf Zechner, Erwin F. Wagner

Highlights

  • WAT browning contributes to high energy expenditure in cancer-associated cachexia
  • Systemic inflammation and IL-6 induce and sustain WAT browning in cachexia
  • Inhibition of WAT browning ameliorates the severity of cachexia
  • Cancer cachexia patients stain positive for UCP1 protein in WAT

Cell Metabolism Available online 17 July 2014. In Press, Corrected Proof — Note to users
DOI: http://dx.doi.org/10.1016/j.cmet.2014.06.011

Fuente: Echa un vistazo al Tweet de @elmundosalud

¿Nos podemos fiar de lo que dice Wikipedia sobre asuntos médicos?

Wikipedia vs Peer-Reviewed Medical Literature for Information About the 10 Most Costly Medical Conditions

Wikipedia vs Medical Articles

Fuente: Echa un vistazo al Tweet de @Skepticscalpel

Ver Abstact y enlace del artículo.

Could HIV self-testing be a game changer in Africa?

Could HIV self-testing be a game changer in Africa?

Source: Thomson Reuters Foundation - Mon, 14 Jul 2014 10:48 GMT

LONDON (Thomson Reuters Foundation) - In Africa, where fewer than half the people know their HIV status, HIV self-testing is being explored as a way of encouraging more individuals, particularly in high risk groups, to know their status as a first step to seeking treatment, an AIDS charity said on Monday.

Despite decades of investment in testing and counselling for the human immunodeficiency virus (HIV) that causes AIDS, only about 15 percent of Zambians, 25 percent of South Africans and 39 percent of Swazis had been tested for HIV in 2011, U.N. figures show. In Botswana, the rate was higher with 62 percent of the population tested for HIV in 2011.

Experts say one of the main reasons people in sub-Saharan Africa used to give for not getting tested 10 or 15 years ago was the lack of treatment for HIV. But today, drugs that can control the virus for decades are increasingly available.

"Some people continue to live in denial. But we also know that some people don't know their status because of stigma and discrimination," said Felicitas Chiganze, chief operating officer of the Southern African AIDS Trust, which works on the response to HIV in six African countries.

The group published legal research on Monday comparing laws and outlining the human rights implications of HIV self-testing in 10 countries: Botswana, Malawi, Mozambique, Tanzania, Zambia and Zimbabwe where it works, and the United States, France, Britain and South Africa.

"We felt that if there was some initiative or some method that would enable people to know their status without going through some of the formal channels, that this could actually contribute to increasing the uptake for HIV testing," Chiganze told Thomson Reuters Foundation by telephone from Johannesburg.

She said sex workers and men who have sex with men are among the groups facing the heaviest burden of HIV, yet are some of the most hard to reach in terms of testing and treatment.

HPV and Cancer - National Cancer Institute

Asco apunta a la lucha contra el HPV para reducir el Ca. oral

HPV is the Driving Force behind the Rise of Oropharyngeal Cancer

Online Exclusives
14 Jul 2014 7:03 PM

Echa un vistazo al Tweet de @ASCO

Fuente: Connection ASCO.org

Alarmante incremento de infecciones por VIH en Cataluña

10/07/2014 - ForumLibertas.com Diario Digital

El sida “se ha incrementado significativamente” en Cataluña: el 81% de los nuevos casos en Barcelona se da entre homosexuales. El VIH entre el colectivo gay registrado en territorio catalán aumentó un 7,6% anual entre 2001 y 2011 y supone más del 61% de los nuevos diagnósticos. "En diez años podríamos encontrarnos con una alarmante situación en la que más del 40% de los hombres que tienen sexo con hombres entre 40 y 50 años de edad vivirían con el VIH", alerta un informe

CDC promociona las vacunas contra el HPV

Increasing HPV vaccination rates can prevent 50,000 cases of cervical cancer!

New cancer diagnoses registered in England 2012

Echa un vistazo al Tweet de @CDCSTD

Fuente: CDC_Cancer

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Admin Eusalud

Global Engage's. Digital Pathology Congress 2014


UNDERSTANDING & UTILIZING DIGITAL PATHOLOGY AS A TOOL FOR ADVANCING PATHOLOGY PRACTICE AND ENABLING ENHANCED PATIENT CARE

2014 Agenda Just Launched Download the PDF Brochure

Early Registration - delegates save 20% with discount code:NN/EB/20 Offer ends Friday 1 August, 2014*

| Speakers | Free Newsletter | Register today |

Dear If you are involved with Pathology then you are standing at the frontier of fundamental change in technology that will have a huge impact on health care strategies, health care delivery and work patterns. Understanding how is essential.

"Once data is available digitally, it opens up huge opportunities to redesign process-driven services to create patient-centric care systems. Digitally enabled laboratory medicine services have the potential to bring pathologists closer to patients and so to speed up and improve the patient experience."

National
Pathology Programme NHS
 

To secure these benefits, investment into Digital Pathology by health service providers is growing world-wide.

By coming to this outstanding meeting you will discover how Digital Pathology is already reducing lab costs, increasing workflow efficiency, creating greater inter-connectivity and delivering more effective training! Additionally, you will learn how digital pathology can improve decision making to enable
enhanced and personalised patient care.

The Digital Pathology Congress has been designed to target the following strategic and scientific key areas:

  • Digital Pathology - Strategy and Technology
  • Pathology Informatics
  • Telepathology
  • Digital Image Analysis
  • Digital Pathology
  • Application and Research Case Studies

10 most common cancers among males and females in UK 2012

10 most common cancers among males and females in UK 2012

New cancer diagnoses registered in England 2012

Key findings

  • The three most common cancers for men in 2012 remained prostate (25.9%), lung (13.6%) and colorectal (13.4%).
  • The three most common cancers for women in 2012 remained breast (30.9%), lung (11.9%) and colorectal (10.9%).
  • Liver cancer incidence has increased by 70% for males and 60% for females from 2003 to 2012. This is now the 18th most common cancer in England.
  • Malignant melanoma, a type of skin cancer, has increased by 78% among males and 48% among females from 2003 to 2012. This is now the fifth most common cancer in England.
  • Cancer incidence was more than 5% higher than expected in the north of England (North East and North West), and more than 5% lower than expected in London.
Get all the tables for this publication in the data section of this publication.

Fuente: Office National Statistics > Statistical bulletin: Cancer Registration Statistics, England, 2012
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Admin Eusalud

Una buena idea: Dejar de fumar (campaña en español)

Esté libre del Tabaco. Esta es la campaña en español lanzada en los EEUU por el HHS.gov U.S. Department of Health & Human Services: espanol.smokefree.gov

La campaña se ha difundido, entre otros medios, a través de Twitter desde las cuentas @HHGov y @NCImcMedia Echa un vistazo al Tweet de @NICmdMedia : Here is a Spanish version of the article on Smoking & Cancer for the LGBT Community: http://1.usa.gov/1xj0dis

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Una buena idea: Dejar de fumar

Esté libre del Tabaco. Esta es la campaña lanzada en los EEUU por el HHS.gov U.S. Department of Health & Human Services: BeTobaccoFree.gov

Role of Pathologist - CAP

La campaña se ha difiundido, entre otros medios, a través de Twitter desde la cuenta @HHGov. Echa un vistazo al Tweet de @HHSGov

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Admin Eusalud