Datasets and Tissue Pathways

The College's Standards and Datasets for Histopathology Reporting on Cancers and Tissue Pathways have been written to help pathologists work towards a consistent approach for the reporting of the more common cancers and to define the range of acceptable practice in handling pathology specimens. The table in their web page provides links to the cancer dataset documents and to the 'tissue pathways' for non-malignant diseases for each site. NICE has accredited the process used by The Royal College of Pathologists to produce its Cancer Datasets and Tissue Pathways guidance. Accreditation is valid for five years from July 2012 and is retrospectively applicable to documents produced using the processes described in our 2012 guidelines for writing datasets and tissue pathways. All guidance produced following the accredited process bears the NICE accreditation mark. More information on accreditation can be viewed at nice.org.uk/acreditation

Click for more information on datasets, tissue pathways and the Working Group on Cancer Services, including guidance for authors.

Fuente: Datasets and Tissue Pathways

HIV in the United States – Statistics Overview – Statistics Center – HIV/AIDS.

Figure: Estimated New HIV Infections in the United States, 2010, for the Most Affected Subpopulations

Fast Facts

• More than 1.1 million people in the United States are living with HIV infection, and almost 1 in 6 (15.8%) are unaware of their infection.
• Gay, bisexual, and other men who have sex with men (MSMa), particularly young black/African American MSM, are most seriously affected by HIV.
• By race, blacks/African Americans face the most severe burden of HIV.

Fuente: HIV in the United States: At A Glance

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A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

Michele Petruzzelli, Martina Schweiger, Renate Schreiber, Ramon Campos-Olivas, Maria Tsoli, John Allen, Michael Swarbrick, Stefan Rose-John, Mercedes Rincon, Graham Robertson, Rudolf Zechner, Erwin F. Wagner

Highlights

• WAT browning contributes to high energy expenditure in cancer-associated cachexia
• Systemic inflammation and IL-6 induce and sustain WAT browning in cachexia
• Inhibition of WAT browning ameliorates the severity of cachexia
• Cancer cachexia patients stain positive for UCP1 protein in WAT

Cell Metabolism Available online 17 July 2014. In Press, Corrected Proof — Note to users
DOI: http://dx.doi.org/10.1016/j.cmet.2014.06.011

Fuente: Echa un vistazo al Tweet de @elmundosalud

Wikipedia vs Peer-Reviewed Medical Literature for Information About the 10 Most Costly Medical Conditions

Fuente: Echa un vistazo al Tweet de @Skepticscalpel

Ver Abstact y enlace del artículo.

Could HIV self-testing be a game changer in Africa?

Source: Thomson Reuters Foundation - Mon, 14 Jul 2014 10:48 GMT

LONDON (Thomson Reuters Foundation) - In Africa, where fewer than half the people know their HIV status, HIV self-testing is being explored as a way of encouraging more individuals, particularly in high risk groups, to know their status as a first step to seeking treatment, an AIDS charity said on Monday.

Despite decades of investment in testing and counselling for the human immunodeficiency virus (HIV) that causes AIDS, only about 15 percent of Zambians, 25 percent of South Africans and 39 percent of Swazis had been tested for HIV in 2011, U.N. figures show. In Botswana, the rate was higher with 62 percent of the population tested for HIV in 2011.

Experts say one of the main reasons people in sub-Saharan Africa used to give for not getting tested 10 or 15 years ago was the lack of treatment for HIV. But today, drugs that can control the virus for decades are increasingly available.

"Some people continue to live in denial. But we also know that some people don't know their status because of stigma and discrimination," said Felicitas Chiganze, chief operating officer of the Southern African AIDS Trust, which works on the response to HIV in six African countries.

The group published legal research on Monday comparing laws and outlining the human rights implications of HIV self-testing in 10 countries: Botswana, Malawi, Mozambique, Tanzania, Zambia and Zimbabwe where it works, and the United States, France, Britain and South Africa.

"We felt that if there was some initiative or some method that would enable people to know their status without going through some of the formal channels, that this could actually contribute to increasing the uptake for HIV testing," Chiganze told Thomson Reuters Foundation by telephone from Johannesburg.

She said sex workers and men who have sex with men are among the groups facing the heaviest burden of HIV, yet are some of the most hard to reach in terms of testing and treatment.

National Cancer Institute: HPV and Cancer. Reviewed: 03/15/2012

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HPV is the Driving Force behind the Rise of Oropharyngeal Cancer

Online Exclusives
14 Jul 2014 7:03 PM

Echa un vistazo al Tweet de @ASCO

Fuente: Connection ASCO.org

10/07/2014 - ForumLibertas.com Diario Digital

El sida “se ha incrementado significativamente” en Cataluña: el 81% de los nuevos casos en Barcelona se da entre homosexuales. El VIH entre el colectivo gay registrado en territorio catalán aumentó un 7,6% anual entre 2001 y 2011 y supone más del 61% de los nuevos diagnósticos. "En diez años podríamos encontrarnos con una alarmante situación en la que más del 40% de los hombres que tienen sexo con hombres entre 40 y 50 años de edad vivirían con el VIH", alerta un informe

Increasing HPV vaccination rates can prevent 50,000 cases of cervical cancer!

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Fuente: CDC_Cancer

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UNDERSTANDING & UTILIZING DIGITAL PATHOLOGY AS A TOOL FOR ADVANCING PATHOLOGY PRACTICE AND ENABLING ENHANCED PATIENT CARE

2014 Agenda Just Launched Download the PDF Brochure

Early Registration - delegates save 20% with discount code:NN/EB/20 Offer ends Friday 1 August, 2014*

| Speakers | Free Newsletter | Register today |

Dear If you are involved with Pathology then you are standing at the frontier of fundamental change in technology that will have a huge impact on health care strategies, health care delivery and work patterns. Understanding how is essential.

"Once data is available digitally, it opens up huge opportunities to redesign process-driven services to create patient-centric care systems. Digitally enabled laboratory medicine services have the potential to bring pathologists closer to patients and so to speed up and improve the patient experience."

National
Pathology Programme NHS 

10 most common cancers among males and females in UK 2012

Fuente: Office National Statistics > Statistical bulletin: Cancer Registration Statistics, England, 2012
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Esté libre del Tabaco. Esta es la campaña en español lanzada en los EEUU por el HHS.gov U.S. Department of Health & Human Services: espanol.smokefree.gov

La campaña se ha difundido, entre otros medios, a través de Twitter desde las cuentas @HHGov y @NCImcMedia Echa un vistazo al Tweet de @NICmdMedia : Here is a Spanish version of the article on Smoking & Cancer for the LGBT Community: http://1.usa.gov/1xj0dis

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Esté libre del Tabaco. Esta es la campaña lanzada en los EEUU por el HHS.gov U.S. Department of Health & Human Services: BeTobaccoFree.gov

La campaña se ha difiundido, entre otros medios, a través de Twitter desde la cuenta @HHGov. Echa un vistazo al Tweet de @HHSGov

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Are human polyomaviruses co-factors for cancers induced by other oncoviruses?

Ugo Moens1, Marijke Van Ghelue, and Bernhard Ehlers

SUMMARY: Presently, 12 human polyomaviruses are known: BK polyomavirus (BKPyV), JCPyV, KIPyV, WUPyV, Merkel cell polyomavirus (MCPyV), HPyV6, HPyV7, Trichodysplasia spinulosa-associated polyomavirus, HPyV9, HPyV10, STLPyV and HPyV12. In addition, the non-human primate polyomavirus simian virus 40 (SV40) seems to circulate in the human population. MCPyV was first described in 2008 and is now accepted to be an etiological factor in about 80% of the rare but aggressive skin cancer Merkel cell carcinoma. SV40, BKPyV and JCPyV or part of their genomes can transform cells, including human cells, and induce tumours in animal models. Moreover, DNA and RNA sequences and proteins of these three viruses have been discovered in tumour tissue. Despite these observations, their role in cancer remains controversial. So far, an association between cancer and the other human polyomaviruses is lacking. Because human polyomavirus DNA has been found in a broad spectrum of cell types, simultaneous dwelling with other oncogenic viruses is possible. Co-infecting human polyomaviruses may therefore act as a co-factor in the development of cancer, including those induced by other oncoviruses. Reviewing studies that report co-infection with human polyomaviruses and other tumour viruses in cancer tissue fail to detect a clear link between co-infection and cancer. Directions for future studies to elaborate on a possible auxiliary role of human polyomaviruses in cancer are suggested, and the mechanisms by which human polyomaviruses may synergize with other viruses in oncogenic transformation are discussed. Copyright © 2014 John Wiley & Sons, Ltd.

Rev Med Virol 2014 1099-1654. DOI - 10.1002/rmv.1798

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Characterization of two new monoclonal antibodies against human papillomavirus type 16 L1 protein

Yan Wang, Qinglong Shang, Weizhen Xu, Di Li, Hongxi Gu and Lanlan Wei

Background: Human papillomavirus type 16 (HPV16) infection is implicated in cervical carcinogenesis. This study aimed to characterize two new monoclonal antibodies (mAbs) against HPV L1 protein. Methods: The immunocompetence of AE3 and AG7 mAbs for HPV L1 protein was evaluated by Western blot analysis, immunostaining, hemagglutination inhibition assay, and ELISA. The heavy chain variable region (VH) and light chain variable region (VL) of AE3 and AG7 mAbs were sequenced and analyzed. Results: Both mAbs specifically recognized HPV16 L1 and virus-like particles (VLPs). Both the affinity and the titer of AE3 mAb were higher than that of AG7. There were differences in sequences in the complementary determining regions (CDR) 2 and 3 of VL, as well as in the CDR1 and CDR3 of VH. The two mAbs have distinct predicted three-dimensional structures. Conclusions: We characterized two mAbs neutralizing antibodies for HPV L1 protein, which would help develop genetic-engineered neutralizing antibodies against HPV16 for diagnostic and therapeutic purposes.

Diagnostic Pathology 2014, 9:101 doi:10.1186/1746-1596-9-101

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