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VPH y cáncer de laringe

Correlation of Laryngeal Squamous Cell Carcinoma and Infections with Either HHV-8 or HPV16/18

Nema Mohamadian Roshaa, Amirhossein Jafariaa, Hossein Ayatollah, Kiarash Ghazvini, Seyyed Abbas Tabatabaee

Abstract: Each year more than 159,000 new cases of laryngeal cancer are diagnosed globally, and more than 9000 patients die due to this malignancy. Viral infections are a known risk factor for this malignancy. Thus, this study aimed to evaluate the role of HPV-16/18 and HHV-8 infection in patients with laryngeal cancer. In this case–control study, 60 formalin-fixed, paraffin-embedded samples of laryngeal cancer and 22 normal larynx tissue samples from the Pathology Department of Qaem Hospital, Mashhad, Iran were studied. After validating the diagnosis, the samples were evaluated for the detection of HPV-16/18 and HHV-8 DNA using PCR technique. The data were registered and analyzed using SPSS 18.0. The average age for patients and controls was 61.29 ± 11.89 and 55.77 ± 10.10, respectively. Fifty-four patients (90%) and 16 (72.7%) controls were male. PCR results detected no HPV-16/18 DNA in both groups. Although there were 2 positive HHV-8 samples in both laryngeal cancer and normal larynx samples, no significant relation was present (p = 0.291). We found no significant relationship between infection with HHV-8 or HPV-16/18 and the existence of laryngeal cancer. However, more complementary studies are required to re-evaluate our results using more samples and better viral detection techniques.

Pathology - Research and Practice. Available online 12 December 2013.

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Una única dosis de la vacuna VPH puede ser válida

One dose of HPV vaccine may be sufficient to prevent cervical cancer - ONA

Kathy Boltz, PhD
November 20, 2013

Women vaccinated with one dose of a human papillomavirus (HPV) vaccine had antibodies against the viruses that remained stable in their blood for 4 years, suggesting that a single dose of vaccine may be sufficient to generate long-term immune responses and protection against new HPV infections, and ultimately cervical cancer, according to a new study.

"The latest Morbidity and Mortality Weekly Report from the Centers for Disease Control and Prevention on vaccination coverage indicates that in 2012, only 53.8% of girls between 13 and 17 years old initiated HPV vaccination, and only 33.4% of them received all three doses," said lead author Mahboobeh Safaeian, PhD, an investigator in the Division of Cancer Epidemiology and Genetics at the National Cancer Institute (NCI) in Bethesda, Maryland.

12th European Congress on Digital Pathology

12th European Congress on Digital Pathology

previously European Congress on Telepathology and International Congress on Virtual Microscopy

Worldwide INDUSTRY, RESEARCH and CLINICS participants:

   - Business processes in Pathology: hospital integration, telepathology, e-learning
   - Imaging technological advances: WSI, molecular imaging, label free technologies...
   - Image analysis, knowledge formalization and modeling

Organized under the presidency of Catherine Guettier SFP (French Society of  Pathology), honorary president, Etienne Martin with the contribution of ADICAP (Association for Developing Informatics in Cytology and Anatomic Pathology), Frédérique Capron and GFHC (French Group for Cellular Haematology),
Xavier Troussard.

Dear Sir / Madam,

we would like to invite you to the 12th European Congress on Digital Pathology, previously kwown as European Congress on Telepathology and International Congress on Virtual Microscopy, to be held in Paris, France from 18 to 21 June 2014.

Pathology switch from analogue to digital is at the centre of the Congress, as shown in the agenda below. This congress represents a great chance to learn about latest and future innovations and we warmly invite you, your colleagues and partners to attend this biennial European event with participants from all over the world.

This edition of the Congress is organized under the presidence of Catherine Guettier SFP (French Society of Pathology), honorary president, Etienne Martin
with the contribution of ADICAP (Association for Developing Informatics in Cytology and Anatomic Pathology), Frédérique Capron and GFHC (French Group for Cellular Haematology), Xavier Troussard.


Abstracts submission deadline: 20 January 2014

- Contributors are invited to submit an abstract (max. 400 words) written in English for oral and poster presentations on all research fields related to digital pathology, telepathology, image analysis. Specific topics include (and are not limited to) the topics from the provisional agenda underneath.

- Submission should be done electronically at the following link: before 20 January 2014

- In addition, contributors who also aim at individually Pubmed indexed articles shall submit an extended abstract (less than 1500 words). Selected articles will be published either in "Diagnostic Pathology" (editor-in-chief Klaus Kayser, co-chairs Catherine Bor, Philippe Camparo and Myriam Oger) or for computer science oriented articles in the "Computerized Medical Imaging and Graphics" Elsevier journal (editor-in-chief Daniel Racoceanu, co-chair Philippe Belhomme)

NEW! Pecha kucha - a great opportunity for young scientists and creative senior researchers!
Pecha kucha is a special form for very dynamic and exciting presentations. You will have the chance to present your topic/idea/projects (no limits!) for discussion, idea mining and potential collaborators.
The rules of Pecha kucha are very simple: you have 20 slides, for each slide exactly 20 seconds to speak (for the complete presentation 6 min 40 sec). For this session maximal seven words per slide are allowed, you have to use images, figures and diagrams to present you scientific topic, question, idea and/or opinion. This strict format keeps presentations creative, concise and fast-paced and avoids the "Powerpoint-Death"Â (more details:
Please send only your name and title of the Pecha kucha-Presentation to: - no abstracts are necessary.

Organizing committee co-chaired by Jacques Klossa and Philippe Bertheau: Philippe Belhomme; Catherine Bor; Philippe Camparo; Odile Crepin; Christel Daniel; Bettina Fabiani; Vincent Leymarie; Daniel Lusina; Michel Manfait; Etienne Martin; Myriam Oger; Daniel Racoceanu; Thomas Schrader; Béatrice Vergier

Scientific advisory board co-chaired by Klaus Kayser, Catherine Bor and Daniel Racoceanu

Provisional agenda

Wednesday 18 June, 2014
IHE/DICOM joint meeting and at the same time "Young colleagues training session"
Congress opening at 18:00

Thursday 19 June, 2014
Keynote on telepathology
- Telepathology
- Image analysis
- Digital pathology / Virtual microscopy / Technological advances
- Posters presentation and session - PECHA KUCHA for young students

Friday 20 June, 2014
Keynote on knowledge formalization
- Knowledge formalisation
- E- learning
- Image analysis
- Posters presentation and session - PECHA KUCHA for young students

Saturday 21 June, 2014
Keynote on data mining and modeling
- Data mining
- Models in pathology
- Quality of experience

Organizing Secretariat

the office

in collaboration with
Meeting di Sara Zanazzi

For any further information or request, please visit the Congress website or contact the Organizing Secretariat.

Best regards,

Luciana Biecker

HPV&HIV en lesiones de ano

Human papillomavirus genotypes in human immunodeficiency virus-positive patients with anal pathology in Madrid, Spain.

Benjamín García-Espinosa, Ernesto Moro-Rodríguez and Emilio Álvarez-Fernández

Background: We studied anal specimens to determine the distribution of human papillomavirus (HPV) genotypes and co-infection occurrence. This information will contribute to the knowledge of HPV genotype distributions and provide an estimate of the prevalence of different oncogenic HPV genotypes found in patients in Madrid (Spain). Methods: We studied a total of 82 anal biopsies from the Hospital General Universitario Gregorio Marañón of Madrid. These included 4 specimens with benign lesions, 52 specimens with low-grade anal squamous intraepithelial lesion, 24 specimens with high-grade anal squamous intraepithelial lesions and 2 specimens with invasive anal carcinoma. HPV genotyping was performed with PCR amplification and reverse dot blot hybridization. Results: We detected 33 different HPV genotypes, including 16 HPVs associated with a high risk of carcinogenesis, 3 HPVs associated with a highly likely risk of carcinogenesis and 14 HPVs associated with a low-risk of carcinogenesis. In two specimens, an uncharacterized HPV genotype was detected. The most frequent HPV genotypes found were HPV-16 (10.3%; 95% CI: 6.6%-15.1%), HPV-52 (8.5%; 95% CI: 5.2%-13%) and HPV-43/44 (7.6%; 95% CI: 4.5%-11.9%). HPV-18 was only detected in 0.9% (95% CI: 0.1%-3.2%) of the total viruses detected in all lesions. HPV co-infections were found in 83.9% of all types of lesions. The majority of cases (90.2%) were concomitantly infected with the human immunodeficiency virus (HIV). Conclusion: The prevalence of high-risk carcinogenic genotypes in anal pathological samples was remarkable. Therefore, further studies that include a greater number of samples, particularly invasive carcinoma cases are needed to evaluate the potential influence of these HPV genotypes in the appearance of anal carcinomas. Also, the influence of other accompanying infections should be evaluated clarify the appearance of this type of carcinoma.

Diagnostic Pathology 2013, 8:204 doi:10.1186/1746-1596-8-204

Published: 10 December 2013


El CDC alerta no hay tratamientos milagro contra el cáncer

Estafas de tratamiento contra el cáncer | Información para consumidores

Admin Eusalud

Human papillomavirus-associated oral intraepithelial neoplasia: Modern Pathology

Human papillomavirus-associated oral intraepithelial neoplasia.

Sook-Bin Woo, Emma C Cashman and Mark A Lerman

Abstact: This study evaluated an unusual subset of oral epithelial dysplasia for the presence of transcriptionally active high-risk HPV subtypes and to further characterize the histological criteria for this condition. There were 20 cases diagnosed as epithelial dysplasia with marked apoptosis of the anterior oral cavity. Clinical and follow-up data were collected and histopathological features were documented. Immunoperoxidase studies were performed for p16 and in situ hybridization studies were performed for low- and high-risk HPV sub-types. Gender- and site-matched controls of conventional moderate-to-severe oral epithelial dysplasia were similarly evaluated using immunoperoxidase studies for p16 and in situ hybridization; the number of apoptotic cells for study and control cases was counted at two different tissue sites. There were 17 men and 3 women with a median age of 56 years. Seventeen lesions were described as white and five were described as rough or papillary. Thirteen were located on the lateral or ventral tongue, some extending onto the floor of the mouth. Epithelial hyperplasia with marked karyorrhexis and apoptosis were present in all the cases, along with features of conventional oral epithelial dysplasia. A statistically significant number of apoptotic cells were identified in the study cases when compared with controls (P>0.0001). Twenty cases were positive for high-risk HPV by in situ hybridization and all 19 nineteen cases evaluated for p16 demonstrated overexpression. Two patients were diagnosed with squamous cell carcinomas and one patient developed recurrent disease. We report a subset of oral epithelial dysplasia that occurs mostly in adult men on the ventral or lateral tongue and is positive for high-risk HPV and for p16. We propose use of the term ‘HPV-associated Oral Intraepithelial Neoplasia’ to characterize these lesions of the oral cavity for consistency in nomenclature with HPV-associated lesions of the lower anogenital tract. One case recurred and one developed invasive cancer.

Modern Pathology 26, 1288-1297 (October 2013) doi:10.1038/modpathol.2013.70

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Eficacia del Cribado para VPH en The Lancet

Screening for HPV May Be Better Than Pap Test, Study Suggests: MedlinePlus

Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials

Guglielmo Ronco, Joakim Dillner, K Miriam Elfström, Sara Tunesi, Peter J F Snijders, Marc Arbyn, Henry Kitchener, Nereo Segnan, Clare Gilham, Paolo Giorgi-Rossi, Johannes Berkhof, Julian Peto, Chris J L M Meijer. The International HPV screening working group†

NIH VideCasting y PodCasting

Evalución de nódulos pulmonares en TAC como riesgo de cáncer de pulmón

NEJM - Risk of Cancer in a CT-Discovered Nodule

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10 extensiones libres de Google Chrome para docentes

Prevalencia de infecciones anales por HPV en USA

Human Papillomavirus Prevalence in Invasive Anal Cancers in the United States Before Vaccine Introduction

Steinau, Martin; Unger, Elizabeth R.; Hernandez, Brenda Y. ; Goodman, Marc T.; Copeland, Glenn; Hopenhayn, Claudia; Cozen, Wendy; Saber, Maria S.; Huang, Youjie; Peters, Edward S.; Lynch, Charles F.; Wilkinson, Edward J.; Rajeevan, Mangalathu S.; Lyu, Christopher; Saraiya, Mona

Cursos on-line en MOOC

Base de datos de marcadores para IHQ

Pathpedia: Database of immunohistochemical markers

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Revistas de Patología

Pathpedia: Pathology journals

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El CDC se pronuncia sobre el Screening cervical

Centers for Disease Control and Prevention. Gynecologic Cancers: Cervical Cancer Screening.

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