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ESTUDIO DESCRIPTIVO DE SÍNDROME INMOVILIDAD PACIENTE GERIÁTRICO

ESTUDIO DESCRIPTIVO DE SÍNDROME INMOVILIDAD PACIENTE GERIÁTRICO - Lucía Román, Ricardo Ariel Ovejero. Unidad Geriatría. Hospital Durand. Buenos Aires. Argentina [Rev Electron Biomed]

Real Decreto 767/2014 por el que se establece el título de Técnico Superior en Anatomía Patológica y Citodiagnóstico

MINISTERIOR DE EDUACIÓN, CULTURA Y DEPORTE

Real Decreto 767/2014, de 12 de septiembre, por el que se establece el título de Técnico Superior en Anatomía Patológica y Citodiagnóstico y se fijan sus enseñanzas mínimas. [Pag. 10064]

Fuente: http://www.boe.es - http://www.boe.es/buscar/doc.php?id=BOE-A-2014-10064

Pathology911

An online pathology resource for surgical pathology trainees across the globe

An online pathology resource for surgical pathology trainees across the globe: Path-o-Blog, Path-o-Snap and Links.

URL: http://pathology911.com/

Rev Electron Autopsia 2014;12(1)

Rev Electron Autopsia Vol 12, No 1 (2014)

Revista Electrónica de la Autopsia

Tabla de contenidos


Editorial

Nueva etapa en la Revista Electrónica de la Autopsia: La autopsia une a la Anatomía Patológica y a la Patología Forense PDF
Joaquín S. Lucena Romero 1-3


Patología Autópsica Pediátrica

Importancia de la autopsia fetal en casos de abortos espontáneos. PDF
Tanya Kitova, Le Vinh, Borislav Kitov, Radoslav Minkov 4-7


Pathology Resident Wiki: Pathology Links

The Pathology Resident Wiki!
The wiki about Pathology that anyone can edit.

Pathology Links

The Human Protein Atlas

The Human Protein Atlas

Here you can search for a gene or protein and find protein expression profiles based on immunohistochemistry for a large number of human tissues, cancers and cell lines, subcellular localization in three cell lines, transcript expression levels in three cell lines or use Fields in the Search function to build your own query to find all proteins expressed in a certain organ or specific tissue, located in a certain subcellular compartment or differentially expressed in a given tumor type. Go to search examples.

Site: proteinatlas.org: The Human Protein Atlas

Cancers of the anal canal: diagnosis, treatment and future strategies

Cancers of the anal canal: diagnosis, treatment and future strategies

Emma Bown, Vikas Shah, Thiagarajan Sridhar, Kirsten Boyle, David Hemingway, Justin M Yeung

ABSTRACT: Anal cancer is an uncommon cancer; however, it is rising in incidence. There is confusion regarding nomenclature and the distinction between anal canal cancer and anal margin cancer. This article discusses the modern definition, etiology and staging of anal canal and anal margin cancers. Modern chemotherapy and radiotherapy regimens are discussed, in addition to modern imaging and radiotherapy techniques. Future preventative strategies and potential novel treatments are discussed.

Future Oncology, June 2014, Vol. 10, No. 8 , Pages 1427-1441
doi: 10.2217/fon.14.23

What if pathologists didn't exist?

Thursday, June 06, 2013

What if pathologists didn't exist?

Most of the world has no idea what pathologists do, short of the forensic ones who appear on T.V. in crime-related shows. Even many of our clinician colleagues don't fully understand what is involved in our work. Medical charts are typically full of verbiage indicating that, "the specimen was sent to pathology and the diagnosis came back..." as if this all happens magically in a "black box." Tissue is inserted into a machine and the diagnosis comes out the other end. Well... maybe one day but not in my (or your) lifetimes.

One of our former residents tipped me off to the link below from the Royal College of Pathologists of Australasia (RCPA). If you've never attended one of their meetings and are looking for a good reason to visit the land down under, I strongly recommend it. The RCPA decided to have a little fun with the concept of what medicine would be like without a pathologic underpinning.

http://worldwithoutpathology.rcpa.edu.au/

The site begins with the following message:

"If Pathologists didn't exist where would the answers come from? Pathology is the study of the nature and causes of diseases. It underpins every aspect of medicine, from diagnosis to monitoring, and is vital for research. Without pathologists, any answers found would be questionable to say the least. Every medical test, a case of trial and error. Exactly the kind of words you don't want to hear when it comes to your health. Watch the videos and see for yourself."

What follows then is series of short, very well done and admittedly quite silly videos with the serious premise that without pathologists clinicians would be absolutely clueless about diagnosing disease. Much like tribal "witch doctors" they might be relegated to devising and using all sorts of impractical, irreproducible, and completely non-functional schemes to aid in diagnosis. If you need a good laugh check this out. Afterwards think about what this says about our pivotal role in medicine. If you have non-medical friends who want to know if you're a "real doctor," and they have a good sense of humor, pass this link on to them!

Posted by Stacey E. Mills, MD at 2:34 PM

Fuente: Pⁿ Blog

The Pⁿ Blog is a forum for opinions, questions, controversies, and instructive discussions across the field of pathology and its relevant subspecialties.

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Admin

The Occasional Role of Low-risk Human Papillomaviruses 6, 11, 42, 44, and 70 in Anogenital Carcinoma

The Occasional Role of Low-risk Human Papillomaviruses 6, 11, 42, 44, and 70 in Anogenital Carcinoma Defined by Laser Capture Microdissection/PCR Methodology: Results From a Global Study

Guimerà, Núria; Lloveras, Belén; Lindeman, Jan; Alemany, Laia; van de Sandt, Miekel; Alejojo, Maria; Hernandez-Suarez, Gustavo; Bravo, Ignacio G.; Molijn, Anco; Jenkins, David; Cubilla, Antonio; Muñoz, Nubia; de Sanjose, Silvia; Bosch, Francesc Xavier; Quint, Wim

Abstract: Low-risk human papillomaviruses (LR-HPVs) have been associated occasionally with clinically and pathologically unusual anogenital malignancies. The relation between clinicopathologic features and any pathogenetic role of LR-HPV remains unclear. From a global study of 13,328 anogenital carcinomas, we identified 57 cases in which whole-tissue polymerase chain reaction using SPF10-LiPA25 showed single LR-HPV infection. In 43/46 (93.5%) available carcinomas, multiple polymerase chain reaction assays confirmed single detection of HPV6, 11, 42, 44, or 70 DNA. In 75% (n=32) of these, LR-HPV DNA was confirmed in tumor cells by laser capture microdissection. In 2 cases, including 1 adenocarcinoma, viral DNA was only found outside the tumor. All anogenital tumors with confirmed HPV6/11 showed a distinctive range of papillary, warty or warty-basaloid, squamous, or transitional histology with patchy or negative p16INK4a expression. HPV6-associated cervical tumors occurred at a low median age. HPV42/70 was associated with typical squamous cell carcinoma showing diffuse p16INK4a staining like high-risk HPV–related malignancies. HPV44 was found in malignant cells in 1 case. Viral taxonomy and theoretical analysis show that HPV6/11 belong to a different genus from HPV42/70 with E6/E7 gene products that would not bind pRb or p53, whereas HPV42/70 could bind pRb. Our data support the causal involvement of LR-HPVs in the carcinogenesis of <2% of anogenital malignancies of 2 distinct clinicopathologic patterns related to the genetic structure of the HPV types 6/11 and 70/42. HPV42/70 was associated with typical squamous carcinomas. Importantly all carcinomas associated with HPV6/11 globally showed verruco-papillary, well-differentiated, squamous, or transitional histology without p16INK4a expression.

Am J Surg Pathol September 2013 - Volume 37 - Issue 9 - p 1299–1310
doi: 10.1097/PAS.0b013e31828b6be4

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Admin

Data Science Toolbox

Start doing data science in minutes

Data Science Toolbox

As a data scientist, you don't want to waste your time installing software. Our goal is to provide a virtual environment that will enable you to start doing data science in a matter of minutes.

As a teacher, author, or organization, making sure that your students, readers, or members have the same software installed is not straightforward. This open source project will enable you to easily create custom software and data bundles for the Data Science Toolbox.

datasciencetoolbox.org

Datasets and Tissue Pathways

Datasets and Tissue Pathways

The Royal College of Pathologist

The College's Standards and Datasets for Histopathology Reporting on Cancers and Tissue Pathways have been written to help pathologists work towards a consistent approach for the reporting of the more common cancers and to define the range of acceptable practice in handling pathology specimens. The table in their web page provides links to the cancer dataset documents and to the 'tissue pathways' for non-malignant diseases for each site. NICE has accredited the process used by The Royal College of Pathologists to produce its Cancer Datasets and Tissue Pathways guidance. Accreditation is valid for five years from July 2012 and is retrospectively applicable to documents produced using the processes described in our 2012 guidelines for writing datasets and tissue pathways. All guidance produced following the accredited process bears the NICE accreditation mark. More information on accreditation can be viewed at nice.org.uk/acreditation

Click for more information on datasets, tissue pathways and the Working Group on Cancer Services, including guidance for authors.

Fuente: Datasets and Tissue Pathways

Sida en EE.UU.

HIV in the United States – Statistics Overview – Statistics Center – HIV/AIDS.

Figure: Estimated New HIV Infections in the United States, 2010, for the Most Affected Subpopulations

CDC - HIV in the United States: At A Glance

Fast Facts

  • More than 1.1 million people in the United States are living with HIV infection, and almost 1 in 6 (15.8%) are unaware of their infection.
  • Gay, bisexual, and other men who have sex with men (MSMa), particularly young black/African American MSM, are most seriously affected by HIV.
  • By race, blacks/African Americans face the most severe burden of HIV.

Fuente: HIV in the United States: At A Glance

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Admin Eusalud

Elucinan la causa de la caquexia en pacientes con cáncer

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

Michele Petruzzelli, Martina Schweiger, Renate Schreiber, Ramon Campos-Olivas, Maria Tsoli, John Allen, Michael Swarbrick, Stefan Rose-John, Mercedes Rincon, Graham Robertson, Rudolf Zechner, Erwin F. Wagner

Highlights

  • WAT browning contributes to high energy expenditure in cancer-associated cachexia
  • Systemic inflammation and IL-6 induce and sustain WAT browning in cachexia
  • Inhibition of WAT browning ameliorates the severity of cachexia
  • Cancer cachexia patients stain positive for UCP1 protein in WAT

Cell Metabolism Available online 17 July 2014. In Press, Corrected Proof — Note to users
DOI: http://dx.doi.org/10.1016/j.cmet.2014.06.011

Fuente: Echa un vistazo al Tweet de @elmundosalud

¿Nos podemos fiar de lo que dice Wikipedia sobre asuntos médicos?

Wikipedia vs Peer-Reviewed Medical Literature for Information About the 10 Most Costly Medical Conditions

Wikipedia vs Medical Articles

Fuente: Echa un vistazo al Tweet de @Skepticscalpel

Ver Abstact y enlace del artículo.

Could HIV self-testing be a game changer in Africa?

Could HIV self-testing be a game changer in Africa?

Source: Thomson Reuters Foundation - Mon, 14 Jul 2014 10:48 GMT

LONDON (Thomson Reuters Foundation) - In Africa, where fewer than half the people know their HIV status, HIV self-testing is being explored as a way of encouraging more individuals, particularly in high risk groups, to know their status as a first step to seeking treatment, an AIDS charity said on Monday.

Despite decades of investment in testing and counselling for the human immunodeficiency virus (HIV) that causes AIDS, only about 15 percent of Zambians, 25 percent of South Africans and 39 percent of Swazis had been tested for HIV in 2011, U.N. figures show. In Botswana, the rate was higher with 62 percent of the population tested for HIV in 2011.

Experts say one of the main reasons people in sub-Saharan Africa used to give for not getting tested 10 or 15 years ago was the lack of treatment for HIV. But today, drugs that can control the virus for decades are increasingly available.

"Some people continue to live in denial. But we also know that some people don't know their status because of stigma and discrimination," said Felicitas Chiganze, chief operating officer of the Southern African AIDS Trust, which works on the response to HIV in six African countries.

The group published legal research on Monday comparing laws and outlining the human rights implications of HIV self-testing in 10 countries: Botswana, Malawi, Mozambique, Tanzania, Zambia and Zimbabwe where it works, and the United States, France, Britain and South Africa.

"We felt that if there was some initiative or some method that would enable people to know their status without going through some of the formal channels, that this could actually contribute to increasing the uptake for HIV testing," Chiganze told Thomson Reuters Foundation by telephone from Johannesburg.

She said sex workers and men who have sex with men are among the groups facing the heaviest burden of HIV, yet are some of the most hard to reach in terms of testing and treatment.