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Rev Electron Autopsia 2014;12(1)

Rev Electron Autopsia Vol 12, No 1 (2014)

Revista Electrónica de la Autopsia

Tabla de contenidos


Nueva etapa en la Revista Electrónica de la Autopsia: La autopsia une a la Anatomía Patológica y a la Patología Forense PDF
Joaquín S. Lucena Romero 1-3

Patología Autópsica Pediátrica

Importancia de la autopsia fetal en casos de abortos espontáneos. PDF
Tanya Kitova, Le Vinh, Borislav Kitov, Radoslav Minkov 4-7

REA/EJAutopsy en las redes sociales


Revista Electrónica de la Autopsia


Estimado lector de la Revista Electrónica de la Autopsia:


Queremos informarte que nuestra revista está presente ya en las redes sociales. Se acaba de crear una cuenta en Twitter bajo el nombre @EJAutopsy a través de la cual os enviaremos información puntual de los artículos que vayamos publicando y de otra información que pudiera ser de vuestro interés tanto sobre la autopsia clínica como forense. Ya sabes que si dispones de una cuenta en Twitter te invitamos a que nos sigas.


Además puedes encontrarnos también en Facebook.


Aprovechamos finalmente la ocasión para animaros a enviar vuestros manuscritos a la Revista Electrónica de la Autopsia. No lo dejéis para mañana. Los esperamos.

Recibe un cordial saludo
Equipo Editor de la Rev Electon Autopsia

SOS Aborto (24 horas)

LÍNEA 24 HORAS EN ESPAÑA: 693 632 326

Rescatadores Juan Pablo II: Desde el respeto a la mujer y la voluntad firme de querer ayudarla, recluta "personas apasionadas por ayudar a mujeres en situación de vida o muerte para sus hijos".

Leer más en: Recursos para embarazadas - Red Madre y Escuela de Rescatadores Juan Pablo II

¿Qué hace un patólogo?


The College of American Pathologists (CAP), the leading organization of board-certified pathologists.

Northfield, IL

Fuente: Tweet de @Pathologists


RENAL DISEASE AND CARDIOVASCULAR RISK: A GLOBAL VIEW - Nephrology Division. Hospital Italiano de Buenos Aires. Argentina [Rev Electron Biomed]


TROMBOCITOPENIA ALOINMUNE DEL FETO Y EL NEONATO: A PROPÓSITO DE 2 CASOS - Servicio de Pediatría, del Centro de Salud Gamonal-Antigua. Servicio de Hematología-Hemoterapia. Hospital Universitario de Burgos. Burgos. España [Rev Electron Biomed]

La OMS informa sobre la gripe asiática (en inglés)

Frequently Asked Questions on Middle East respiratory syndrome coronavirus (MERS‐CoV)

12 June 2015


Fuente: Tweet de @WHO - OMS/WHO


CONSIDERACIONES SOBRE MODELOS DE FORMACIÓN Y PRÁCTICA MÉDICAS. ¿INNOVACIÓN O RENOVACIÓN? - EDITORIAL /EDITORIAL. Profesor Honorario de la Facultad de Ciencias Médicas y Miembro del Consejo de Investigaciones de la
Universidad Nacional de Rosario. Rosario. Argentina.
[Rev Electron Biomed]

ETSs en números

Incidence, Prevalence, and Cost of Sexually Transmitted Infections in the United States


CDC’s estimates of sexually transmitted infections in United States, 2008:

  • Annual new infections - (Incidence) 20 million
  • Total infections (Prevalence) 110 million
  • Total medical costs $16 billion

In February 2013, CDC published two analyses that provide an in-depth look at the severe human and economic burden of sexually transmitted infections (STIs) in the United States.

CDC’s new estimates show that there are about 20 million new infections in the United States each year, costing the American healthcare system
nearly $16 billion in direct medical costs alone.

America’s youth shoulder a substantial burden of these infections. CDC estimates that half of all new STIs in the country occur among young men and women. In addition, CDC published an overall estimate of the number of prevalent STIs in the nation. Prevalence is the total number of new and existing infections at a given time. CDC’s new data suggest that there are more than 110 million total STIs among men and women across the nation.

CDC’s analyses included eight common STIs: chlamydia, gonorrhea,
hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2), human immunodeficiency virus (HIV), human papillomavirus (HPV), syphilis, and trichomoniasis.

Fuente: Tweet de @CDCSTD - CDC FACT SHEET

The 2014 Bethesda System

Cancer Cytopathology
The Pap test and Bethesda 2014

Ritu Nayar MD and David C. Wilbur

Abstract: The history of “The Bethesda System” for reporting cervical cytology goes back almost 3 decades. This terminology and the process that created it have had a profound impact on the practice of cervical cytology for laboratorians and clinicians alike. Herein, we summarize the process and rationale by which updates were made to the terminology in 2014 and outline the contents of the new, third edition of the Bethesda atlas and corresponding website.

Cancer Cytopathology 2015; 123(5):271–281

Sobre la vacuna del VPH

Tips and Time-savers for Talking with Parents About HPV Vaccine
CDC research shows these straightforward messages are important to parents when discussing HPV vaccine-and easy for you or your staff to deliver. Parents may be interested in vaccinating, yet still have questions. Taking the time to listen to parents questions helps you save time and give an effective response.

Adobe PDF file Download page

Recommend the HPV vaccine series the same way you recommend the other adolescent vaccines. For example, you can say "Your child needs these shots today," and name the all of the vaccines recommended for the child’s age.

"Parents may be interested in vaccinating, yet still have questions. Taking the time to listen to parents’ questions helps you save time and give an effective response. CDC research shows these straightforward messages work with parents when discussing HPV vaccine—and are easy for you or your staff to deliver."

Carcinogenic HPV infection in the cervical squamo-columnar junction

Carcinogenic HPV infection in the cervical squamo-columnar junction

Mirkovic J, Howitt BE, Roncarati P, Demoulin S, Suarez-Carmona M, Hubert P, McKeon FD, Xian W, Li A, Delvenne P, Crum1 CP, Herfs M

Abstract: Recent studies have suggested the involvement of a unique population of cells at the cervical squamo-columnar junction (SCJ) in the pathogenesis of early (squamous intraepithelial lesion or SIL) and advanced (squamous cell and adeno-carcinomas) cervical neoplasia. However, there is little evidence to date showing that SCJ cells harbour carcinogenic HPV or are instrumental in the initial phases of neoplasia. This study was designed to (1) determine if normal-appearing SCJ cells contained evidence of carcinogenic HPV infection and (2) trace their transition to early SIL. Sections of cervix from high-risk reproductive age women were selected and SCJ cells were analysed by using several techniques which increasingly implicated HPV infection: HPV DNA (genotyping and in situ hybridization)/RNA (PCR), immunostaining for HPV16 E2 (an early marker of HPV infection), p16ink4, Ki67, and HPV L1 protein. In 22 cases with a history of SIL and no evidence of preneoplastic lesion in the excision specimen, HPV DNA was isolated from eight of ten with visible SCJ cells, six of which were HPV16/18 DNA-positive. In five of these latter cases, the SCJ cells were positive for p16ink4 and/or HPV E2. Transcriptionally active HPV infection (E6/E7 mRNAs) was also detected in microdissected SCJ cells. Early squamous atypia associated with the SCJ cells demonstrated in addition diffuse p16ink4 immunoreactivity, elevated proliferative index, and rare L1 antigen positivity. We present for the first time direct evidence that normal-appearing SCJ cells can be infected by carcinogenic HPV. They initially express HPV E2 and their progression to SIL is heralded by an expanding metaplastic progeny with increased proliferation and p16ink4 expression. Whether certain SCJs are more vulnerable than others to carcinogenic HPV genotypes and what variables determine transition to high-grade SIL remain unresolved, but the common event appears to be a vulnerable cell at the SCJ. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

The Journal of Pathology. 2015; 236(3):265–271 DOI: 10.1002/path.4533



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CancerLinQ can contribute to high-quality, personalized cancer care for every patient.


Aumento de incidencia de Cáncer de Colon y su conexión con el VPH

Dr. Monica Malik

Rising Rates of Sporadic Colorectal Cancer in Young Adults: A Possible Environmental by Dr. Monica Malik

Key Points

The estimated annual incidence of colorectal cancer (CRC) worldwide is 1.3 million, making it the third most common cancer in males and the second most common cancer in females.

There is an increase in CRC incidence in low-income countries and a significantly higher proportion of early-onset cancers.

There is a rising incidence of CRC in young adults from diverse geographic and ethnic backgrounds, which could be linked to environmental pollution or lifestyle factors, such as obesity, physical inactivity, and a diet rich in processed foods.

Possible HPV Connection

Certain oncogenic subtypes of HPV have been conclusively implicated in cancers of the cervix, head and neck, and anal canal. Many investigators have attempted to find an association between HPV and CRC, with discrepant results. Recently, two meta-analyses with data from 16 and 37 studies showed a 10-fold and 6-fold higher risk of CRC with HPV positivity, respectively. More specifically, HPV prevalence varied by geographical region, with the highest prevalence in South America, followed by Asia and the Middle East, suggesting a possible correlation linking high-risk sexual behavior, lifestyle, and HPV infection with CRC rates in resource-constrained countries. Laskar et al.26 detected HPV DNA in 31.2% of patients with RC in their study, of which 76% had HPV subtype 18, 8% had subtype 16, 8% had both subtypes 16 and 18, and 8% had subtypes other than 18 and 16.

Fuente: ASCO Daily News, May 30, 2015