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Rev Electron Autopsia 2014;12(1)

Rev Electron Autopsia Vol 12, No 1 (2014)

Revista Electrónica de la Autopsia

Tabla de contenidos


Nueva etapa en la Revista Electrónica de la Autopsia: La autopsia une a la Anatomía Patológica y a la Patología Forense PDF
Joaquín S. Lucena Romero 1-3

Patología Autópsica Pediátrica

Importancia de la autopsia fetal en casos de abortos espontáneos. PDF
Tanya Kitova, Le Vinh, Borislav Kitov, Radoslav Minkov 4-7

REA/EJAutopsy en las redes sociales


Revista Electrónica de la Autopsia


Estimado lector de la Revista Electrónica de la Autopsia:


Queremos informarte que nuestra revista está presente ya en las redes sociales. Se acaba de crear una cuenta en Twitter bajo el nombre @EJAutopsy a través de la cual os enviaremos información puntual de los artículos que vayamos publicando y de otra información que pudiera ser de vuestro interés tanto sobre la autopsia clínica como forense. Ya sabes que si dispones de una cuenta en Twitter te invitamos a que nos sigas.


Además puedes encontrarnos también en Facebook.


Aprovechamos finalmente la ocasión para animaros a enviar vuestros manuscritos a la Revista Electrónica de la Autopsia. No lo dejéis para mañana. Los esperamos.

Recibe un cordial saludo
Equipo Editor de la Rev Electon Autopsia

SOS Aborto (24 horas)

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Rescatadores Juan Pablo II: Desde el respeto a la mujer y la voluntad firme de querer ayudarla, recluta "personas apasionadas por ayudar a mujeres en situación de vida o muerte para sus hijos".

Leer más en: Recursos para embarazadas - Red Madre y Escuela de Rescatadores Juan Pablo II

Gardasil 9

Echa un vistazo al Tweet de @theNCI:

Subclasificacion del Ca de vagina

Echa un vistazo al Tweet de @memoalexlope:

Aumenta la incidencia de los tumores de cabeza y cuello causados por VPH

Increase in Head and Neck Cancer in Younger Patients Due to Human Papillomavirus (HPV)

D Young, CC Xiao, B Murphy, M Moore, C Fakhry, TA Day

The face of head and neck cancer has changed dramatically over the past 30 years. There has been a steady decline in the number of tobacco and alcohol related squamous cell carcinomas over the past 30 years, but and increasing incidence of human papillomavirus (HPV) related cancers. Some estimates suggest that 70–90% of new oropharyngeal cancers have evidence of HPV.

These patients have different demographic patterns, in that they are more likely to be younger, white adults in their 40 s and 50 s who are never smokers or have reduced tobacco exposure. Studies have shown that a higher number of lifetime oral sex partners (>5) and a higher number of lifetime vaginal sex partners (>25) have been associated with increased risk of HPV positive head and neck cancer. People can also reduce their risk of HPV linked head and neck cancer by receiving the HPV vaccine series prior to becoming sexually active. Recent evidence suggests HPV related head and neck cancers present with different symptoms than those caused by tobacco. The most popular test for HPV status is the p16 immunohistochemical stain because it is cheap, simple, and studies have shown it to have comparable sensitivity and specificity to the previous standards. It is widely recommended that all cancers of the oropharynx be tested for the presence of HPV, and some recommend it for all head and neck cancers. Overall 2-year and 5-year survival for HPV positive head and neck cancer is significantly greater than for HPV negative cancers, likely due to HPV positive cancers being more responsive to treatment. Copyright © 2015 Elsevier Inc. All rights reserved.

PMID: 26066977
Oral Oncol 2015 Aug;51(8):727-30 [EPub Ahead of Print]
Tweet de @memoalexlope

TRIG Working Group

Preparing Pathologists for a Leading Role in Genomics


In 2010, the Training Residents in Genomics (TRIG) Working Group was formed through the Pathology Residency Directors Section (PRODS) of the Association of Pathology Chairs (APC). The goals of this group, made up of experts in medical education, molecular pathology, and clinical genetics, are to develop teaching tools, and promote genomic pathology education. The TRIG Working Group represents a unique collaborative effort in pathology education with members from many major pathology organizations and representatives from the National Society of Genetic Counselors, American College of Medical Genetics and Genomics, and the National Coalition for Health Provider Education in Genetics.

The TRIG Working Group has held genomic pathology workshops and courses at the annual meetings of major pathology organizations. An Instructor Handbook and Toolkit are now available to enable residency programs to locally implement similar training.

Based on their accomplishments, the TRIG Working Group received in 2012 an R25 grant from the National Cancer Institute. Providing approximately $1.3 million over five years, this funding will be used, with design support from ASCP, to develop additional educational resources such as online modules as well as assessment tools to determine curriculum efficacy. The specific aims of the grant are:

  • Aim #1.- To develop a pathology resident genomic medicine curriculum, with a major focus on cancer care, as well as tools for national implementation.”
  • Aim #2.- To evaluate the curriculum using a pre/post-test design at four pathology residency programs using validated assessment tools.”
  • Aim #3.- To promote curriculum implementation using the resources of major national pathology organizations so that >90% of pathology residency programs nationwide have high-quality training in cancer genomics by the end of year 5.”
  • Aim #4.- To assess the degree of nationwide implementation and efficacy of curricula in genomic medicine using the pathology resident in-service exam (RISE).”


Stratification of HPV-induced cervical pathology using the virally encoded molecular marker E4 in combination with p16 or MCM

Stratification of HPV-induced cervical pathology using the virally encoded molecular marker E4 in combination with p16 or MCM

Heather Griffin, Yasmina Soneji, Romy Van Baars, Rupali Arora, David Jenkins, Miekel van de Sandt, Zhonglin Wu, Wim Quint, Robert Jach, Krzysztof Okon, Hubert Huras, Albert Singer and John Doorbar

Abstract: High-risk human papillomavirus (HPV) types cause cervical lesions of varying severity, ranging from transient productive infections to high-grade neoplasia. Disease stratification requires the examination of lesional pathology, and possibly also the detection of biomarkers. P16INK4a and MCM are established surrogates of high-risk HPV E6/E7 activity, and can be extensively expressed in high-grade lesions. Here we have combined these two cellular biomarkers with detection of the abundant HPV-encoded E4 protein in order to identify both productive and transforming lesions. This approach has allowed us to distinguish true papillomavirus infections from similar pathologies, and has allowed us to divide the heterogeneous CIN2 category into those that are CIN1-like and express E4, and those that more closely resemble nonproductive CIN3. To achieve this, 530 lesional areas were evaluated according to standard pathology criteria and by using a multiple staining approach that allows us to superimpose biomarker patterns either singly or in combination onto an annotated hematoxylin and eosin (H&E) image. Conventional grading of neoplasia was established by review panel, and compared directly with the composite molecular pathology visualized on the same tissue section. The detection of E4 coincided with the onset of vacuolation, becoming abundant in koilocytes as the MCM marker declined and cells lost their defined nuclear margins as visualized by standard H&E staining. Of the dual marker approaches, p16INK4a and E4 appeared most promising, with E4 generally identifying areas of low-grade disease even when p16INK4a was present. Extensive p16INK4a expression usually coincided with an absence of E4 expression or its focal retention in sporadic cells within the lesion. Our results suggest that a straightforward molecular evaluation of HPV life-cycle deregulation in cervical neoplasia may help improve disease stratification, and that this can be achieved using complementary molecular biomarker pairs such as MCM/E4 or, more promisingly, p16INK4a/E4 as an adjunct to conventional pathology.

Modern Pathology 28, 977-993 (July 2015) | doi:10.1038/modpathol.2015.52

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The College of American Pathologists (CAP), the leading organization of board-certified pathologists.

Northfield, IL

Fuente: Tweet de @Pathologists


RENAL DISEASE AND CARDIOVASCULAR RISK: A GLOBAL VIEW - Nephrology Division. Hospital Italiano de Buenos Aires. Argentina [Rev Electron Biomed]


TROMBOCITOPENIA ALOINMUNE DEL FETO Y EL NEONATO: A PROPÓSITO DE 2 CASOS - Servicio de Pediatría, del Centro de Salud Gamonal-Antigua. Servicio de Hematología-Hemoterapia. Hospital Universitario de Burgos. Burgos. España [Rev Electron Biomed]

La OMS informa sobre la gripe asiática (en inglés)

Frequently Asked Questions on Middle East respiratory syndrome coronavirus (MERS‐CoV)

12 June 2015


Fuente: Tweet de @WHO - OMS/WHO


CONSIDERACIONES SOBRE MODELOS DE FORMACIÓN Y PRÁCTICA MÉDICAS. ¿INNOVACIÓN O RENOVACIÓN? - EDITORIAL /EDITORIAL. Profesor Honorario de la Facultad de Ciencias Médicas y Miembro del Consejo de Investigaciones de la
Universidad Nacional de Rosario. Rosario. Argentina.
[Rev Electron Biomed]